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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

All of the above analyses were performed using Stata software 13.0 (Stata Corp)

Many of these studies showed reductions in dopamine and metabolite levels in response to HIV, although several showed increases in dopamine and metabolites during acute infection or acute Tat exposure, and these changes were inversely correlated with disease progression (Horn et al., 2013

doi: 10.2147/DDDT.S308713 31 WangGYinYLvRLingXCaoHLiuHet al