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43 The relevance of this pathway for tumorigenesis is demonstrated by the fact that humans with the Laron syndrome, a recessively inherited defect in the growth hormone receptor, display extremely low IGF-1 and reduced insulin concentrations and usually do not develop cancer despite high prevalence of obesity and dyslipidemia

The 0.9% benzyl alcohol holds back bacterial contamination the dominant spoilage path but does not arrest the slower hydrolysis, oxidation, and aggregation processes that accumulate in any aqueous peptide solution

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This pulsatile pattern preserves the negative feedback loop: somatostatin still regulates the system normally between pulses