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Many changes are invisible without imaging, but metabolic dysfunction, insulin resistance, hearing loss, and olfactory changes may appear long before memory changes

Dysregulation of ERAD can lead to the accumulation of misfolded proteins, chronic ER stress, and ultimately, cardiac dysfunction

Materials and methods Animals Wild type (WT) BALB/cJ, recombination-activating gene 2deficient [Rag2 / , C.B6(Cg)-Rag2tm1.1Cgn/J, RRID: IMSR_JAX:008448], and Rag2-deficient chaindeficient (Rag2 / GC / , C;129S4-Rag2tm1.1FlvIl2rgtm1.1Flv/J, RRID: IMSR_JAX:014593) mice were obtained from The Jackson Laboratory

Insights on the Use of -Lipoic Acid for Therapeutic Purposes