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The liver is the main organ for vitamin B 12 storage, excreted in the bile, undergoes extensive enterohepatic recycling, and part of a dose is excreted in the urine

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The "hit-and-clear" model requires rest periods for immune processing Guarantee human results No compound that has only been tested in mice should be assumed to work identically in humans

But in practice, and especially with regard to synthetic and recombinant peptide forms, there are some considerable potential safety concerns: Immunogenicity Most notably, per a 2020 assessment on therapeutic peptide safety, synthetic and recombinant peptides pose the risk of immunogenicity the ability of a substance to provoke an immune response.15 An immunogenicity-inducing peptide, when introduced to the body, would cause the bodys immune system to perceive the peptide not as a medication but as a threat