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Experimental reproducibility remains a concern because curcumins stability and purity vary widely across studies, leading to inconsistent bioavailability and pharmacodynamic outcomes

The exclusion criteria were as follows: a) non-English publications, b) grey literature, conference abstracts, and case reports, c) duplicate entries, d) information on non-plant sources and crude extracts only, e) studies that did not involve NPs, such as those focusing synthetic compounds, and f) lacking of transparent methodology and objectives

Cessna, S

Subsequently, other statin, including lovastatin and simvastatin, were discovered and studied [8, 9]