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GLP-1 RAs remain an essential therapeutic option for patients ineligible for surgery or seeking non-surgical management, though weight regain and long-term cardiovascular outcomes warrant careful consideration, they wrote

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398 In neuronal cells, the CREB family of transcription factors are the main regulators of brain-derived neurotrophic factor ( BDNF ) gene expression, 399 and emerging evidence suggests that NR4A2 mediates BDNF expression in these cells