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In women with gestational diabetes, ~200 mg decreased insulin sensitivity by 18% and increased blood sugar by 19%.[68][70] Caffeine also raises cortisol ~50% above baseline, directly raising blood sugar.[71] Iron depletion: One cup of coffee with a meal reduces non-heme iron absorption by 39%

Gut 69:18071817 Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T, Yang Y, Wang X (2021) Roseburia intestinalis: a beneficial gut organism from the discoveries in genus and species

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