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Rapid administration is the most common cause of cardiovascular side effects, and these effects are almost entirely avoidable with appropriate injection speed

Discouraging clinical read-through: The most advanced human program on the same HGF/c-Met hypothesis (a different molecule, fosgonimeton) failed its primary endpoint in the Phase 2/3 LIFT-AD Alzheimers trial [6] [7]

Animal toxicology shows a wide therapeutic window with no documented LD1

This structural mismatch between BPC-157s biology and standard drug development pathways has contributed to the slow pace of clinical trial development, though it has not diminished scientific interest in the compound