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Pepin M, Schwarze U, Superti-Furga A, Byers PH

In addition to their anti-inflammatory effects, these compounds have inhibitory effects on the following pathways: inflammasome (NLRP3), Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, endothelial cell vascular cell adhesion molecule-1 (VCAM-1) or intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinases involved in remodelling and metastasis (MMP 2, MMP 9), and chronic cycloxogenase derived prostaglandins that promote angiogenesis and immunosuppression (182)

Edwin , and Dr

Patients interested in potential anti-inflammatory benefits should discuss the evidence and limitations with their GP or specialist, recognising that these medications are prescribed primarily for metabolic indications according to NICE guidance