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Bellwether trials are early test cases selected from a larger group of lawsuits

FSTL-1 has an adverse effect on disc homeostasis, accompanied by increased concentrations in the serum of IVDD patients, discs of rats with IVDD, and the cerebrospinal fluid of dogs with IVDD (125, 141)

To avoid collateral effects, more specific modulators of amino acids metabolism can be developed, through the use of monoclonal antibodies, mimetic peptides that activate receptors, proteolysis-targeting chimera degraders, and/or antisense nucleotides targeting genes (receptors, transporters, or enzymes) [252,253,254,255]