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The six-transmembrane epithelial antigen of prostate 3 (STEAP3) and divalent metal transporter 1 (DMT1) are involved in this process (Ohgami et al., 2005)

They may help with pain management and slow further degeneration, but they cannot rebuild a destroyed joint

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In addition, FOXO4-related peptide inhibits the interaction of p53 with FOXO4 to promote p53-medicated apoptosis [10], and the HSP90 inhibitor 17-DMAG impacts the anti-apoptotic PI3K/AKT pathway [11]