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A retrospective study of 94 people using compounded semaglutide with cyanocobalamin showed an average loss of 2.7 kg of fat mass and 1.4 kg of lean mass after three months, compared with prospective studies of brand-name semaglutide, which showed approximately 10 kg of fat mass loss at seven months

The results of a trial of semaglutide in obese patients with HFpEF showed a significant amelioration of symptoms and improvements in motor function and weight loss compared with patients treated with a placebo.470 In this study, researchers randomized 529 patients with heart failure with a preserved ejection fraction and body mass index (weight in kilograms in the square of the height in meters) 30 to receive once-weekly injections of semaglutide (2.4 mg) or placebo for 52 weeks

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Absolute contraindications include personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)