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Among 2,491 U.S

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

It has been used in therapeutic settings for sleep disorders and stress-related conditions with minimal reported complications, making it a safe option when integrated into a personalized health plan

784,786 Monitoring cellular metabolic adaptation, which involves metabolic flexibility and plasticity, remains a significant challenge in understanding metabolic remodeling during liver repair and regeneration