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An important theme in interpreting vitamin B 12 deficiency is the remethylation block hypothesis: Vitamin B 12 deficiency results in hyperhomocysteinemia because Hcy remethylation is blocked (Selhub et al., However, a further examination of this hypothesis, for example using the topology of the metabolic network in Figure 1, shows there might be difficulties with this interpretation

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Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction

doi: 10.1210/jcem.76.4.8473405 [DOI] [PubMed] [Google Scholar] 73.Weber MM