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Some women report weight gain after starting HRTbut heres what might be behind it: Fluid Retention Temporary water weight early on is common but usually resolves

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Rebound Vasodilation : Topical corticosteroids initially cause vasoconstriction, but upon withdrawal, rebound vasodilation occurs due to increased nitric oxide release, resulting in skin erythema

Secondly, the decreasing insulin 1/2 (INS1/2) transcription and the smaller insulin-secreting vesicles are observed after the upregulation of THADA, together leading to the impaired insulin secretion