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This clinical trial was a randomized, double-blind, crossover, placebo-controlled trial lasting 16 weeks
As the body adapts to significant caloric restriction and metabolic changes, temporary periods of low energy may occur
The Evidence: Where They Differ Significantly This is the most important part of the comparison, and where the two options diverge most sharply
Exposures during this time may induce persistent epigenetic differences, which can result in disease later in life or possibly be inherited by the offspring to induce transgenerational effects 38,39,40,41,42
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