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doi: 10.3389/fcimb.2026.1778721 Received 31 December 2025 Revised 10 March 2026 Accepted 12 March 2026 Published 30 March 2026 Volume 16 - 2026 Edited by Bilal i, Ahi Evran University Medicine Faculty Department of Physiology, Trkiye Reviewed by Pengbo Guo, Shandong First Medical University, China Lujian Zhu, Jinhua Central Hospital, China Updates Copyright 2026 Li and Chen

While BPC 159 and BPC 157 may sound similar, they are distinct peptides with unique characteristics

The initial stages, N1 and N2, represent lighter sleep phases, whereas N3, equated with SWS, signifies the deepest phase of sleep

Laboratory studies reveal TB-500 reduces production of inflammatory mediators including TNF- and IL-1 by 55% while enhancing anti-inflammatory IL-10 and TGF- expression, creating balanced immune responses that clear damaged tissue while supporting regeneration