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OHSS, ovarian hyperstimulation syndrome
Together with the pharmacodynamic data, this PK knowledge may help in selecting dosing regimens needed to achieve target exposures that maximize efficacy and minimize toxicity, advancing the translation of 7,8-DHF therapy from preclinical to clinical studies
The choice of therapy depends on the severity of disease, and the response of the patient to prior therapeutic interventions
- Pharmacological Interventions In severe cases, medications such as gabapentinoids (gabapentin, pregabalin), tricyclic antidepressants, or serotonin-norepinephrine reuptake inhibitors (SNRIs) may be prescribed to modulate nerve pain
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