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As semaglutide receptors in your brain become less responsive to the same dose, appetite suppression weakens and weight loss stallstypically between weeks 8 and 16 of treatment

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Consistency with injections and a healthy lifestyle will likely yield the best results

Slower titration is worth considering if: Nausea persists beyond 2 weeks at your current dose You experience significant GI symptoms that interfere with daily function Your body aches or muscle pain are severe You are losing weight faster than 1 to 2 percent of body weight per week (too-rapid weight loss increases muscle loss risk) Some researchers use a 6 or 8-week interval between dose increases instead of the standard 4 weeks