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Subsequently, ChIP assays were performed using anti-p-CREB (cell signaling technology), anti-CBP (cell signaling technology), anti-H3K4me3 (cell signaling technology), or anti-H2AK119ub antibodies (Abcam, United Kingdom) and a negative control comprising normal rabbit IgG (Santa Cruz Biotechnology, Inc., United States)
have proposed that ovarian cancer cells exhibit heightened iron uptake and reduced iron efflux, rendering them more susceptible to erastin both in vitro and in vivo (Yang et al., 2014)
This secretion is enhanced by increased Ca 2+ influx due to several PKA- and EPAC-dependent mechanisms: (1) the inhibition of ATP-regulated K + ion channels, (2) an increase in activity of L-type voltage-gated Ca 2+ channels (VGCCs), and (3) triggering the opening of non-specific cation channels [18,19,20,21]
The impact of drug treatment on GLUT1/6 and SREBP2 expression levels was also evaluated
