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Whole cell GSH abundance (bottom left) and fold change in cell number (log 2 ) of HEK-293T cells expressing a vector control or engineered GshF cDNA treated with indicated BSO concentrations for 5 days (bottom right)

doi: 10.1080/19490976.2020.1758008 189 CuarteroMIde la ParraJGarca-CulebrasABallesterosILizasoainIMoroM

LCN2 drives osteocyte ferroptosis via SLC22A17 under basal and iron overload conditions LCN2-iron-siderophore complexes are internalized through receptor-mediated endocytosis [26], prompting us to examine whether osteocytes express the LCN2 receptor SLC22A17