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10.1038/NRCARDIO.2017.36 36

When the aerosols of 4 commercially available e-liquids chosen from a top 10 list of Best E-Cigarettes of 2014 , were analysed by gas chromatography-mass spectrometry (GCMS) after heating, numerous compounds were detected, with nearly half of them not previously identified [4], thus suggesting that the heating process per se generates new compounds of unknown consequence

Creatinine is the breakdown product of creatine, which is formed in muscle tissue, released into the bloodstream, and excreted in the urine via glomerular filtration of the kidneys [53]