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In addition, accumulated oxygen free radicals in thyroid cells may inhibit TPO function and interfere with the synthesis and secretion of thyroid hormones, causing hypothyroidism (34, 86)

Cellular mechanisms that exist to counteract ROS include stabilization by enzymes such as superoxide dismutase and catalase, and direct scavenging by antioxidant molecules such as glutathione (GSH), a major intracellular antioxidant

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