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While very high oral doses (1,000 to 2,000 mcg) can achieve some passive absorption without intrinsic factor roughly 1% of the dose is absorbed passively many clinicians prefer the reliability and rapid correction offered by injections in this population

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Lean mass rose as a share of total weight, and grip strength improved on semaglutide. Protein, resistance training, and strength trends provide more useful context than the scan ratio alone