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In mice exposed to cigarette smoke over 12 weeks to induce pulmonary emphysema, GHK-Cu reduced markers of both inflammation and oxidative stress, again via the same NF-B-suppressing, Nrf2-boosting mechanism, this time in a chronic disease model rather than an acute one

Deac et al

This, and the fact that APR-246 and system x C inhibitors have been safely trialled in humans 36,37 , should facilitate rapid translation of our findings to improve treatment outcomes for patients with mut-p53 cancers