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As a primary therapeutic option for adolescent PCOS, metformin, whether used either as a standalone therapy or in conjunction with oral contraceptives, can effectively reduce androgen levels, alleviate hyperandrogenism symptoms, restore regular menstrual cycles, ameliorate IR, and reduce the likelihood of long-term cardiovascular complications

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Acceleration phase (Weeks 8-24): As the dose increases toward the therapeutic target, weight loss typically accelerates

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