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Specific genetic associations with distinct SCAR phenotypes have been identified, leading to the implementation of genetic screening before prescription in various countries to prevent SCARs

Moreover, it provides a comprehensive overview of recent advancements in this domain, with particular emphasis on current translational constraints and prospective strategies towards further clinical translation

10.1002/hep.27157 Hepatology 43 SadigharaM.JoktajiJ

The most direct evidence of the role of NRF2 in regulating immune responses is from studies of NRF2-deficient (NRF2 KO) mice which exhibit profound and destructive injury in the setting of immune responses