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To investigate mechanisms underlying FTLD-GRN, single-cell transcriptomics in the thalamus and frontal cortex of Grn / mice and FTLD-GRN patients identified a conserved astrocytic pathology marked by upregulation of GJA1, AQP4 , and Apoe , and downregulation of the glutamate transporter SLC1A2

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Statinfibrate combination therapy is associated with an increased risk for abnormal transaminase levels, myositis, or rhabdomyolysis (26) and does not lower the risk of cardiovascular events more than simvastatin alone (27)