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That said, mild effects can occur in some people, especially when starting any new supplement: Temporary bloating or fullness (more common with collagen) Mild digestive discomfort if taken without enough water These are usually short-lived and can be reduced by: Taking supplements with adequate water Starting with recommended doses Choosing high-quality, well-absorbed formulations Using clinically formulated products from trusted brands helps minimize unnecessary reactions

However, the lack of a significant difference in ROS between the combination group and the GSH monotherapy group indicated that ROS may not have a significant correlation with this synergistic effect, and the specific mechanism needs further research

In vitro , GSH-deficient hepatocytes show upregulated mRNA levels of DNA methyltransferase, Tet2, and Tet3, along with increased Dnmt activity (5-mC) and global DNA methylation levels

Understanding the science behind this treatment is the first step