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Recent evidence shows that HSP70s are involved into transmembrane protein translocation via entropic pulling (Rukes et al., 2024), into the protection of damaged muscle fibers via calcium reuptake from the sarcoplasm to the reticulum (Barfoot et al., 2025), and into the regulation of enzymes that mark proteins with ultraviolet-dependent damage (Zeng et al., 2025)

This discussion pointed out opportunities for more research and advances in the field of polyphenols for the alleviation of radiation-induced inflammation, with the ultimate goal of providing innovative ideas and approaches to improve treatment efficacy and enhance the quality of life for the patients with radiation-induced inflammation (Fig

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