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This is why the 3-month cycle framework exists and why a single injection produces minimal results compared to a structured protocol

PMID: 42314683 Mater Today Bio Met@MPDA rejuvenates BMSC energy metabolism to promote bone regeneration in semaglutide-treated obese periodontitis

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Furthermore, loss of lean muscle mass, which can occur alongside fat loss if protein intake and resistance exercise are inadequate, further reduces metabolic heat production since muscle tissue is metabolically active and generates significant body heat even at rest