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Mazdutide: A Dual GLP-1/Glucagon Receptor Agonist in Early Clinical Evidence Mazdutide (IBI362) is a novel dual GLP-1 and glucagon receptor agonist designed to integrate appetite suppression with increased energy expenditure

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Key considerations include: Disease activity status : Active inflammation may increase susceptibility to adverse effects Nutritional state : Patients already experiencing malabsorption or weight loss may not be appropriate candidates for medications that further reduce appetite Stricture presence : Delayed gastric emptying could theoretically worsen symptoms in patients with bowel narrowing Medication interactions : While subcutaneous semaglutide has minimal effects on most oral drug absorption, specific medications (such as levothyroxine with oral semaglutide/Rybelsus) may require monitoring Hypoglycemia risk : For patients with diabetes using insulin or sulfonylureas, dose reductions of these medications may be needed when starting semaglutide Diabetic retinopathy : Patients with pre-existing diabetic retinopathy should be monitored for worsening eye disease There is currently insufficient evidence to provide definitive guidance, making shared decision-making between patient and healthcare team essential

[DOI] [PubMed] [Google Scholar] 199.Billone P.S., Maretti L., Maurel V., Scaiano J.C