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4.5 Potassium In potassium homeostasis, intra-/extracellular redistribution is the main rapid form of physiological regulation

It has been reported that the excessive ROS generation and metal ions released from internalized metal-based NPs have an impact on multiple cell signaling pathways, mainly including Janus kinase/signal transducers and activators of transcription (JAK-STAT), nuclear factor-kappa-lightchain enhancer of activated B cells (NF-B), Phosphatidylinositol 3-kinase (PI3K)/protein serine threonidase (Akt), mitogen-activated protein kinase (MAPK), and nuclear factor erythroid 2-related factor 2 (Nrf2) (Ko et al., 2016

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The provision of exogenous fatty acids in the TME, such as palmitoleic and oleic acids, can spare OCSCs from iron-transport-induced cell death (95)