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Scientists engineered this analog by replacing the third amino acid (glutamic acid) with arginine and adding a 13-amino-acid extension peptide to its N-terminus

Pernicious anemia occurs more commonly in people who already have diseases that are linked to immune-system abnormalities, such as Graves disease, hypothyroidism (under-functioning thyroid gland), thyroiditis (inflammation of the thyroid), vitiligo, and Addison's disease (adrenocortical insufficiency)

[DOI] [PubMed] [Google Scholar] [150].Home PD, Shamanna P, Stewart M, Yang F, Miller M, Perry C, Carr MC, Efficacy and tolerability of albiglutide versus placebo or pioglitazone over 1 year in people with type 2 diabetes currently taking metformin and glimepiride: HARMONY 5, Diabetes, obesity & metabolism, 17 (2015) 179187

Increased levels of cortisol, the stress hormone, can disrupt blood sugar regulation and lead to extra pounds