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Gupta, Gill, Andrews, and Prausnitz, working in human subjects and published in the Journal of Controlled Release in 2011, used electrical impedance to track how quickly skin reseals its barrier after microneedle insertion, and found that in the absence of occlusion, treated sites recovered their barrier properties quickly, on the order of a couple of hours

10.1111/cas.12529 114 JainM.NilssonR.SharmaS.MadhusudhanN.KitamiT.SouzaA

This results in a reduced appearance of fine lines and improved overall skin texture

Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021