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Given that GLP-1 receptor agonists produce significant weight reduction typically 515% of body weight in clinical trials, with results varying by medication, dosage and individual responsethere is theoretical interest in whether these medications might indirectly improve vasomotor symptoms through weight loss

metformin, sulfonylureas, TZDs, etc.) address only one of the underlying pathophysiology - lowering postprandial glucose levels, but their safety profiles and side effects, such as weight gain and hypoglycemia, may present challenges and limitations in their clinical use

428 A total of 1467 AD patients were randomly assigned to receive 23 mg/d or 10 mg/d donepezil, and the results suggested that 23 mg/d donepezil significantly improved cognitive function compared with 10 mg/d donepezil

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