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As this research is still in its early stages, many articles called for the addition of large randomized controlled trials, further evidence-based studies, and more primary research to aid in providing guidance for perioperative management on patients taking GLP-1 RAs and to further elucidate the impact of these medications on perioperative risks (Chang et al

153 Simultaneously, IL-1 stimulates macrophages and other immune cells to activate the NLRP3 inflammasome, leading to the cleavage of pro-IL-1 into its mature, biologically active form