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The practice comes from observations that continuous peptide use may reduce effectiveness over time and that breaks allow receptor sensitivity to reset

In LUKE Health, this is implemented with dual-layer PostgreSQL triggers: Layer 1: A database trigger on the orders table checks for an active, non-expired prescription matching the compound being ordered Layer 2: A constraint trigger verifies the prescribing provider's license is valid for the patient's state This isn't application logic that a developer might accidentally bypass during a feature update

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In experimental models, it is studied in connection with cellular regeneration, tissue protection, and stress responses