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Homocysteine catabolism is conducted by cystathionine -synthase (CBS), an enzyme dependent on pyridoxal-5-phosphate (derived from vitamin B 6 ), which allows the condensation of homocysteine with serine (Fig

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They found that when using traditional measurement techniques, researchers did not observe differences in brain glutathione levels among people with Alzheimers disease or mild cognitive impairment versus healthy people

Given that HD affects different regions of the brain, its typical clinical manifestations include motor and cognitive disorders, as well as mental and behavioral abnormalities