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P53 is a tumor suppressor gene that inhibits System Xc- uptake by downregulating SLC7A11, affecting GPx4 activity and ultimately inducing ferroptosis ( Ferroptosis in non-alcoholic fatty liver disease/non-alcoholic fatty liver disease-hepatocellular carcinoma Metabolic changes and hepatocyte lip toxicity caused by the ectopic accumulation of free fatty acids (FFAs) in the liver are considered to be the principal causes of liver injury in patients with NAFLD ( Notably, as researches continue, it has been found that ferroptosis in the different stages of NAFLD may variable

IGF-1 LR3 1 is a modified version of human IGF-1, extended by 13 amino acids and featuring a substitution at arginine-3 to reduce binding to IGF-binding proteins (IGFBPs)

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Aging, cellular senescence, and mitochondrial dysfunction