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Moreover, endothelial cell inflammation results in the proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs), thereby fostering intimal thickening and vascular remodeling and accelerating the deposition of atherosclerotic plaques [6]

Tyrosine hydroxylase is the critical enzyme in the synthesis of epinephrine, norepinephrine and dopamine, and tryptophan hydroxylase is the essential enzyme in the synthesis of serotonin

Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1-associated atypical neurofibromas

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