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Finally, the lack of regulatory oversight in many countries regarding dietary supplements compared to pharmaceutical drugs increases the risk of contamination or mislabeling 64 , further highlighting the importance of selecting supplements from reputable manufacturers

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Methods Data sources This retrospective pharmacovigilance study was conducted based on the FDA Adverse Event Reporting System (FAERS) database

In particular, ATP signalling through ionotropic purinergic receptor (P2X4R and P2X7R) was shown to contribute to microglial activation and inflammatory cytokine release