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In a pivotal study published in the Journal of Orthopedic Research, researchers created 0.8 cm segmental bone defects in rabbit radius bones and compared healing across treatment groups

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A disulfide-bound cyclic LAG-3-binding peptide (CVPMTYRAC) interfered with the binding of LAG-3 to HLA-DR, the main ligand of LAG-3, activating CD8 + T cells while reducing the proportion of regulatory T cells 105

Anterior cruciate ligament reconstruction is a very common and successful procedure