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J Neurochem 157(3): 370392

Conclusions This systematic review aimed to evaluate the effects of caffeine and related xanthines on neuroinflammation in rodent models of anxiety and depression

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Sighs are reported to result from activation of a neuronal circuit in the preBtzinger complex/parafacial group 133 while apnea results from direct inhibition of the preBtzinger complex or inhibition of drive to phase-switching neurons in the preBtzinger complex 134