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La sintesi endogena , cio la produzione interna, avviene soprattutto a livello di fegato e reni , ma da sola non sufficiente a coprire il fabbisogno

Data availability All data generated or analyzed during this study are included in this published article

doi: 10.1001/jama.2009.2014, 40 FreetC

It's worth noting that GI symptoms, including potential reflux, often attenuate over time as the body adjusts to treatment, particularly after completing the dose titration period