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For patients with established HF and a reduced left ventricular ejection fraction (LVEF), the LIVE and FIGHT trials studied the effect of 2-year liraglutide use [90, 91]

Treatment should be provided within a specialist weight management service and is recommended for a maximum of 2 years

Dr Almeida also highlights how viral marketing and social media trends have influenced product choices, with some practitioners adopting products because patients requested them rather than because there was robust clinical evidence supporting their use

The large doses of pyridoxine often used (30 to 100 mg per day) may be required only for inherited defects of CBS or severe vitamin B 6 deficiency