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(3) Clinical Gaps : While preclinical data (e.g., berberines 500 mg/kg dose in rats) are promising, human trials are sparse, with only cinnamon, coffee, and wheat fiber tested in modest cohorts

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appetite regulation is biology, and the biology reasserts itself when the medication leaves

To put that in perspective, you'd need massive amounts of oral supplements to come close to these therapeutic doses - and most wouldn't make it to your cells intact