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The human PK parameters were predicted using standard allometry, in vitro to in vivo extrapolation (IVIVE) methods, and PBPK modeling

However, most recent evidence from intervention trials in selenium-replete participants does not support a protective effect of selenium supplementation against cancer

On the reassuring side, and it belongs here too: the authors reported no consistent changes in blood or urine laboratory values including glucose levels and liver function studies or in electrocardiographic findings in either study [11]

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