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What Research Says About Antioxidant Supplementation Timelines Generally Glutathione's weeks-based timeline for visible skin effects is consistent with the broader pattern seen across oral antioxidant and nutrient supplementation research generally vitamin C, collagen peptides, and other ingestible skin-support compounds also show published timelines in the 6-12 week range for visible effects, because they all ultimately depend on the same skin cell renewal biology rather than acting as instant topical treatments

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[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis