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Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells

A derivative of the naturally occurring gastric protein called Body Protection Compound (BPC), BPC-157 is classed as a pentadecapeptide

GPx catalyzes the reduction of hydroperoxides (e.g., H 2 O 2 ) to H 2 O via the oxidation of reduced glutathione (GSH) to its oxidized form (GSSH): or more generally Glutathione peroxidases exhibit a nonsequential ping-pong mechanism involving an oxidation reaction followed by a reduction step (Weaver and Skouta 2022)